N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

Base Information

Chemical Name:N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide
CAS No.:1323369-18-1
Molecular Formula:C₃₈H₃₆F₆N₂O₂
Molecular Weight:666.706
Hs Code.:

Synonyms:N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

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Chemical Property of N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

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Technology Process of N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

There total 2 articles about N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 150553-34-7
2,2-dimethyl-N-[5-methyl-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]-propanamide

: 1323369-18-1
N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

Guidance literature:: With water; copper(II) bis(trifluoromethanesulfonate); bis(trifluoromethanesulfonyl)amide; Selectfluor; In 1,2-dichloro-ethane; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201101391

Reference yield:

: 87995-50-4
N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1323369-18-1
N-(5-(2-tert-butyl-6-methyl-8-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-yl)-3'-(trifluoromethyl)biphenyl-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: water; copper(II) bis(trifluoromethanesulfonate); bis(trifluoromethanesulfonyl)amide; Selectfluor / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; copper(II) bis(trifluoromethanesulfonate); bis(trifluoromethanesulfonyl)amide; Selectfluor; In 1,2-dimethoxyethane; 1,2-dichloro-ethane;
DOI:10.1002/anie.201101391