N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide
CAS No.:87995-50-4
Molecular Formula:C12H16BrNO
Molecular Weight:270.169
Hs Code.:
DSSTox Substance ID:DTXSID70402971
Nikkaji Number:J1.642.817E
Wikidata:Q82206502

Synonyms:N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide;87995-50-4;DTXSID70402971;AKOS000193269;SR-01000418962;SR-01000418962-1

Suppliers and Price of N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:269.04153
Heavy Atom Count:15
Complexity:234

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)NC(=O)C(C)(C)C)Br

Technology Process of N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

There total 5 articles about N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 21354-40-5
2,2-dimethyl-N-(4-methylphenyl)propanamide

: 87995-50-4
N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Guidance literature:: With N-Bromosuccinimide; palladium diacetate; toluene-4-sulfonic acid; In toluene; at 20 ℃; for 1h; chemoselective reaction;
DOI:10.1002/anie.201101606

Reference yield:

: 3282-30-2
pivaloyl chloride

: 87995-50-4
N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / toluene

2: 69 percent / Br₂ / CHCl₃

With bromine; In chloroform; toluene;

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 87995-50-4
N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: N-Bromosuccinimide; palladium diacetate; toluene-4-sulfonic acid / toluene / 1 h / 20 °C

With N-Bromosuccinimide; palladium diacetate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;
DOI:10.1002/anie.201101606