(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

Base Information

Chemical Name:(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one
CAS No.:1168152-08-6
Molecular Formula:C₂₇H₂₆ClN₃O
Molecular Weight:443.976
Hs Code.:

Synonyms:(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

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Chemical Property of (Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

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Technology Process of (Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

There total 7 articles about (Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29608-05-7
1-(4-aminobenzyl)piperidine

: 1168152-03-1
(E)-1-acetyl-6-chloro-3-(ethoxy-phenyl-methylene)-indolin-2-one

: 1168152-08-6
(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: 1-(4-aminobenzyl)piperidine; (E)-1-acetyl-6-chloro-3-(ethoxy-phenyl-methylene)-indolin-2-one; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm900431g

Reference yield:

: 110-89-4
piperidine

: 1168152-08-6
(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: triethylamine / dichloromethane / 16 h / 5 - 20 °C

3: pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane / pyridine / 0.67 h / 70 - 110 °C

4: hydrogenchloride / water; methanol / pH 2 - 3

5: N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5: |Eschenmoser Sulfide Contraction;
DOI:10.1021/acs.joc.1c01269

Reference yield:

: 100-14-1
4-nitrobenzyl chloride

: 1168152-08-6
(Z)-6-chloro-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)-amino]methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: triethylamine / dichloromethane / 16 h / 5 - 20 °C

3: pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane / pyridine / 0.67 h / 70 - 110 °C

4: hydrogenchloride / water; methanol / pH 2 - 3

5: N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5: |Eschenmoser Sulfide Contraction;
DOI:10.1021/acs.joc.1c01269