2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion

Base Information

• Chemical Name: 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion
• CAS No.: 79598-03-1
• Molecular Formula: C₂₁H₁₅BrO₃
• Molecular Weight: 395.252
• Mol file: 79598-03-1.mol

Synonyms:2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion

Chemical Property of 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion

There total 5 articles about 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-bromo-1,3-diphenylpropane-1,3-dione (728-84-7) + phenol (108-95-2,27073-41-2) → 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion (79598-03-1)

Guidance literature:

With C₇₂H₈₀CuN₈O₄⁽¹⁺⁾*F₆P^(1-); potassium carbonate; In acetonitrile; at 50 ℃; for 24h;

DOI:10.1039/d0sc05133k

Reference yield: 69.0%

1-Hydroxy-2-phenoxy-1,3-diphenyl-1-propen-2-on (79597-81-2) → 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion (79598-03-1)

Guidance literature:

With bromine; In methanol;

Reference yield:

1,3-diphenylpropanedione (120-46-7,61346-73-4) → 2-Brom-2-phenoxy-1,3-diphenyl-propan-1,3-dion (79598-03-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / Et₃N, Br₂, 47percent HBr / methanol

2: 1) Et₃N, 2) Cu(CH₃COO)2 / 1) acetone, 90 min, reflux, 2) methanol

3: 70 percent / 50percent H₂SO₄ / diethyl ether

4: 69 percent / Br₂ / methanol

With sulfuric acid; hydrogen bromide; bromine; copper diacetate; triethylamine; In methanol; diethyl ether;

upstream raw materials:

1-Hydroxy-2-phenoxy-1,3-diphenyl-1-propen-2-on

1,3-diphenylpropanedione

2-bromo-1,3-diphenylpropane-1,3-dione

phenol