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Usage

Uses

Used in Pharmaceutical Industry:
2-bromo-1,3-diphenyl-3-propanedione is used as a building block for the synthesis of pharmaceuticals, due to its ability to be incorporated into various drug molecules.
Used in Agrochemical Industry:
2-bromo-1,3-diphenyl-3-propanedione is used as a building block for the synthesis of agrochemicals, contributing to the development of effective crop protection agents.
Used in Organic Synthesis:
2-bromo-1,3-diphenyl-3-propanedione is used as a reagent in organic synthesis, particularly in the preparation of chiral compounds, which are important for the development of enantioselective reactions and the synthesis of enantiomerically pure compounds.
Used in Antitumor Research:
2-bromo-1,3-diphenyl-3-propanedione is used as a potential antitumor agent, as it has been studied for its ability to inhibit tumor growth and progression.
Used in Antioxidant Research:
2-bromo-1,3-diphenyl-3-propanedione is used as a potential antioxidant agent, as it has been studied for its ability to protect cells from oxidative damage.

InChI:InChI=1/C15H11BrO2/c16-13(14(17)11-7-3-1-4-8-11)15(18)12-9-5-2-6-10-12/h1-10,13H

Upstream product

• 60-29-7 diethyl ether 
• 144-62-7 oxalic acid 
• 67-66-3 chloroform 
• 2641-89-6 2,3,5,6-tetrabromohydroquinone 
• 641-45-2 2-(α-hydroxy-benzylidene)-1,3-diphenyl-propane-1,3-dione 
• 7726-95-6 bromine 
• 7647-01-0 hydrogenchloride 
• 872280-03-0 α-bromo-β-methoxy-chalcone 
• 110-86-1 pyridine 
• 500889-68-9 1,3-diphenyl-2-trityl-propane-1,3-dione 
• 64-19-7 acetic acid 
• 861587-13-5 3,3-diethoxy-2-bromo-1,3-diphenyl-propan-1-one 
• 94-41-7 benzalacetophenone 
• 120-46-7 1,3-diphenylpropanedione 

Downstream Products

• 7476-74-6 pyridinium-dibenzoylmethylid 
• 855754-86-8 α,β-diacetoxy-chalcone 
• 120-46-7 1,3-diphenylpropanedione 
• 5784-78-1 phenyl-(3-phenyl-quinoxalin-2-yl)-methanone 
• 17524-82-2 [2-(N-ethyl-anilino)-4-phenyl-thiazol-5-yl]-phenyl-methanone 
• 73161-77-0 [2-(4-fluoro-benzylamino)-4-phenyl-thiazol-5-yl]-phenyl-methanone 
• 4123-33-5 [2-(3-methyl-anilino)-4-phenyl-thiazol-5-yl]-phenyl-methanone 
• 4276-53-3 4-(5-benzoyl-4-phenyl-thiazol-2-ylamino)-benzoic acid ethyl ester 
• 4195-54-4 [2-(2-methyl-anilino)-4-phenyl-thiazol-5-yl]-phenyl-methanone 
• 4276-52-2 [2-(4-iodo-anilino)-4-phenyl-thiazol-5-yl]-phenyl-methanone 
• 4123-32-4 phenyl-1-(4-phenyl-2-phenylamino-1,3-thiazol-5-yl)methanone 
• 643-75-4 1,3-diphenyl-propane-1,2,3-trione 
• 124852-92-2 (3-Methyl-5-phenyl-2-thioxo-2,3-dihydro-oxazol-4-yl)-phenyl-methanone 
• 124852-99-9 6,7-dihydro-2-methyl-5H-1,2,4-thiadiazolo<4,5-a>pyrimidine-3(2H)-thione hydrobromide 

Relevant academic research and scientific papers

A novel photochemical DNA-cleaving agent, brominated dibenzoylmethanes

Novel photochemical DNa-cleaving molecules possessing a dibenzoyldibromomethane chromophore have been prepared. The efficiency and the sequence selectivity for the DNA photocleavage have been described.

Preparation method of compound containing bipyrazole ring and intermediate thereof

The invention discloses a preparation method of a compound containing a bipyrazole ring and an intermediate of the compound. The preparation method of a bipyrazole ring-containing compound as shown ina formula I comprises the following steps: (1) adding alkali into a mixture of a bipyrazole ring compound as shown in a formula I-1 and a solvent for replacement reaction to obtain a mixed system; and (2) adding an organic phosphorus compound shown as a formula I-2 into the mixed system in the step (1), and carrying out a phosphonation reaction shown in the specification, so as to obtain the bipyrazole ring-containing compound shown as the formula I, wherein R1 and R2 are independently a C1-C6 alkyl group, a C3-C8 cycloalkyl group and a phenyl group, R3 is a C1-C6 alkyl group, and X is halogen. The prepared compound containing a bipyrazole ring can be used as a ligand, and is suitable for the application range of amide in C-N coupling and the C-C coupling reaction of arylboronic acid andaryl chloride.

Pyrazolyl bistriazolyl phosphine compound and application of pyrazolyl bistriazolyl phosphine compound

The invention discloses a pyrazolyl bistriazolyl phosphine compound and application thereof. The invention discloses a compound shown as a formula I. In the formula I, R1 is hydrogen, C1-C6 alkyl or phenyl; R2 and R3 are phenyl; R4 and R5 are independently a C1-C6 alkyl group, a C3-C8 cycloalkyl group, or a phenyl group. The pyrazolyl bistriazolyl phosphine compound disclosed by the invention is stable in property, excellent in catalytic effect and high in selectivity, and can be applied to catalytic coupling of amine, boric acid compounds and halides.

Preparation method of pyrazole bistriazolylphosphine compound

The invention discloses a preparation method of a pyrazole bistriazolylphosphine compound. The invention discloses a preparation method of a compound as shown in a formula I. The preparation method comprises the following step: under the action of an alkali, carrying out a phosphonation reaction process as shown in the specification on a compound as shown in a formula II and a compound as shown ina formula III in a solvent in the presence of protective gas to obtain the compound as shown in the formula I, wherein R1 is hydrogen, a C1-C6 alkyl group or a phenyl group, R2 and R3 are phenyl, R4and R5 are independently a C1-C6 alkyl group, a C3-C8 cycloalkyl group or a phenyl group and x is halogen. The pyrazolyl bistriazolylphosphine compound obtained by the preparation method disclosed bythe invention is stable in property, excellent in catalytic effect and high in selectivity, and can be applied to catalytic coupling of amine, boric acid compounds and halides.

Compound containing bipyrazole ring, intermediate thereof and application thereof

The invention discloses a compound containing a bipyrazole ring, and an intermediate and application thereof. The invention provides the compound containing a bipyrazole ring, as shown in a formula Iwhich is described in the specification. The compound can be used as a ligand, is high in selectivity, and is suitable for the application range of amide in C-N coupling and the C-C coupling reactionof arylboronic acid and aryl chloride, especially coupling with aryl chloride.

A Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide

The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.

Solvent-Controlled α-Monobromination, α,α-Dibromination or Imidation of 1,3-Diketones with N-Bromosuccinimide

In this work, we present a solvent-controlled regioselective method for α-monobromination, dibromination or imidation of 1,3-diketones with N-bromosuccinimide under simple reaction conditions. The employment of solvents plays a key role on the reaction selectivity providing α-monobrominated, dibrominated and imidated products. Visible light irradiation accelerates the dibromination reaction of 1,3-diketones. In particular, one important solvent was found to be highly effective for the imidation of 1,3-diketones under base-free condition.

Highly Regio- and Stereodivergent Access to 1,2-Amino Alcohols or 1,4-Fluoro Alcohols by NHC-Catalyzed Ring Opening of Epoxy enals

Described is an unprecedented NHC-catalyzed (NHC=N-heterocyclic carbene), stereoselective ring opening of epoxy and cyclopropyl enals to deliver valuable compounds bearing multiple stereocenters. A straightforward three-step procedure involving two catalytic enantioselective transformations has been developed and leads to a regio- and stereodivergent synthesis of either 1,2-amino alcohols/diamines or 1,4-fluoro alcohols with excellent diastereo- and enantiopurity.

One-pot synthesis of α-bromo- and α-azidoketones from olefins by catalytic oxidation with in situ-generated modified IBX as the key reaction

Simple one-pot protocols for the syntheses of α-bromoketones and α-azidoketones starting from olefins have been developed by employing catalytic oxidation of the intermediary bromohydrins with in situ-generated modified IBX as the key reaction. The improved procedure involves initial formation of bromohydrin by the reaction of olefin with NBS in acetonitrile-water mixture (1:1) at rt followed by oxidation with in situ-generated 3,4,5,6-tetramethyl-2-iodoxybenzoic acid (TetMe-IBX), produced in catalytic amounts from 3,4,5,6-tetramethyl-2-iodobenzoic and Oxone. α-Bromoketones are further converted in the same pot to the corresponding α-azidoketones using NaN3/NaHCO3. The one-pot conversions are versatile for a variety of olefins that include cyclic as well as acyclic aliphatic olefins and electron-rich and electron-deficient styrenes. Chemoselective bromohydroxylation of electron-rich double bond and subsequent oxidation to the α-bromoketone is demonstrated for a substrate that contains both electron-rich and deficient double bonds.

A quick, mild and efficient bromination using a CFBSA/KBr system

Bromination is a fundamental transformation in organic chemistry and brominated compounds as building blocks are of paramount importance in organic synthesis. In our study, we have developed an efficient method of bromination by using a CFBSA/KBr system at room temperature in a short reaction time. Notably, this approach has been proven to be applicable to a range of substrates including 1,3-diketones and β-keto esters, phenols, aromatic amines and heteroarenes with good to excellent yields.