3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Base Information

Chemical Name:3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate
CAS No.:1450018-76-4
Molecular Formula:C₂HF₃O₂*C₂₁H₁₆F₃N₅O
Molecular Weight:525.41
Hs Code.:

Synonyms:3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Suppliers and Price of 3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

There total 5 articles about 3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188301-65-6
5-(5-bromo-2-(4-trifluoromethyl)phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxypyridin-2-amine

: 1692-15-5
4-pyridylboronic acid

: 76-05-1
trifluoroacetic acid

: 1450018-76-4
3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Guidance literature:: 5-(5-bromo-2-(4-trifluoromethyl)phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxypyridin-2-amine; 4-pyridylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 23h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 1450018-76-4
3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

1.2: pH 8 / Cooling with ice

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C / Inert atmosphere

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 23 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; bromine; potassium acetate; sodium carbonate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; 3.1: |Suzuki Coupling / 4.1: |Suzuki Coupling;

Reference yield:

: 42409-58-5
5-bromo-3-methoxy-pyridin-2-amine

: 1450018-76-4
3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 23 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;