tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

Base Information

Chemical Name:tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate
CAS No.:1005779-31-6
Molecular Formula:C₂₅H₂₂F₃N₅O₄
Molecular Weight:513.476
Hs Code.:

Synonyms:tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

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Chemical Property of tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

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Technology Process of tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

There total 7 articles about tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1005779-28-1
6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylic acid

: 1005779-31-6
tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In ethyl acetate; tert-butyl alcohol;

Reference yield:

: C₂₅H₂₁F₃N₄O₄

: 1005779-31-6
tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

Guidance literature:: With diphenylphosphoranyl azide; In tetrahydrofuran; at 20 - 100 ℃; for 14.1667h;
DOI:10.1021/jm300126x

Reference yield:

: 1005786-10-6
ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate

: 1005779-31-6
tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 150 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

3: water; sodium hydroxide / methanol / 4 h / 20 °C

4: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

5: diphenylphosphoranyl azide / tetrahydrofuran / 14.17 h / 20 - 100 °C

With diphenylphosphoranyl azide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 5: Curtius rearrangement;
DOI:10.1021/jm300126x