ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate

Base Information

• Chemical Name: ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate
• CAS No.: 1005779-25-8
• Molecular Formula: C₂₃H₁₇F₃N₄O₄
• Molecular Weight: 470.408

Synonyms:ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate

Chemical Property of ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate

Chemical Property:

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Technology Process of ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate

There total 2 articles about ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-carboxylate (1005779-22-5) + 3-(trifluoromethyl)benzoic acid (454-92-2) → ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate (1005779-25-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jm300126x

Reference yield:

ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate (1005786-10-6) → ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate (1005779-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 150 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm300126x

Reference yield: 96.0%

ethyl 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylate (1005779-25-8) → 6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylic acid (1005779-28-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; water;

upstream raw materials:

ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate

ethyl 6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-carboxylate

3-(trifluoromethyl)benzoic acid

Downstream raw materials:

6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylic acid

N-{6-[3-({[3-(trifluoromethyl)phenyl]carbonyl}amino)-phenoxy]imidazo[1,2-b]pyridazin-2-yl}tetrahydro-2H-pyran-4-carboxamide

N-(3-{[2-(propionylamino)imidazo[1,2-b]pyridazin-6-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide

tert-butyl[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]-pyridazin-2-yl]carbamate

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