4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

Base Information

Chemical Name:4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide
CAS No.:1227160-21-5
Molecular Formula:C₁₃H₁₇FN₂O₂
Molecular Weight:252.289
Hs Code.:

Synonyms:4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

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Chemical Property of 4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

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Technology Process of 4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

There total 5 articles about 4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1227160-24-8
4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]benzonitrile

: 1227160-21-5
4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; at 80 ℃; for 2h;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1227160-21-5
4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 2 h / 0 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / -78 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1227160-22-6
ethyl 4-(4-bromophenyl)tetrahydro-2H-pyran-4-carboxylate

: 1227160-21-5
4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / -78 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;