(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1227159-63-8
Molecular Formula:C₃₁H₃₅FN₆O₃
Molecular Weight:558.656
Hs Code.:

(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

Synonyms:(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

There total 6 articles about (3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1227160-21-5
4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide

: 1227160-52-2
5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid hydrochloride

: 1227159-63-8
(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: 5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]-N'-hydroxybenzenecarboximide amide; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 0.666667h;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1227159-63-8
(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 2 h / 0 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / -78 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 0.67 h / 20 - 140 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1227160-22-6
ethyl 4-(4-bromophenyl)tetrahydro-2H-pyran-4-carboxylate

: 1227159-63-8
(3-{[3-(3-{4-[4-(fluoromethyl)tetrahydro-2H-pyran-4-yl]phenyl}-1,2,4-oxadiazol-5-yl)-5-methyl-1H-pyrazol-1-yl]methyl}phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / -78 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 0.67 h / 20 - 140 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;