Technology Process of 5-(3-fluorophenyl)-1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
There total 5 articles about 5-(3-fluorophenyl)-1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; barium(II) hydroxide;
In
acetic acid butyl ester; water;
at 80 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2-methyltetrahydrofuran / 0.08 h / 30 °C / Inert atmosphere
1.2: 1.25 h / 0 - 5 °C / Inert atmosphere
2.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydride / mineral oil; tetrahydrofuran / 18 h
3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
3.2: 1.5 h / -78 °C
4.1: barium(II) hydroxide; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride / water; acetic acid butyl ester / 0.5 h / 80 °C
With
n-butyllithium; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; mineral oil;
4.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydride / mineral oil; tetrahydrofuran / 18 h
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
2.2: 1.5 h / -78 °C
3.1: barium(II) hydroxide; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride / water; acetic acid butyl ester / 0.5 h / 80 °C
With
n-butyllithium; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide;
In
tetrahydrofuran; acetic acid butyl ester; water; mineral oil;
3.1: |Suzuki Coupling;
