5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Base Information

Chemical Name:5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
CAS No.:1613622-54-0
Molecular Formula:C₁₄H₁₂FN₃O₂
Molecular Weight:273.267
Hs Code.:

Synonyms:5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

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Chemical Property of 5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

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Technology Process of 5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

There total 6 articles about 5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613623-85-0
5-(3-fluorophenyl)-1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613622-54-0
5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 60 ℃; for 6h;

Reference yield:

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1613622-54-0
5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: barium(II) hydroxide; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride / water; acetic acid butyl ester / 0.5 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 60 °C

With [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; tetrabutyl ammonium fluoride; barium(II) hydroxide; In tetrahydrofuran; acetic acid butyl ester; water; 1: |Suzuki Coupling;

Reference yield:

: 874-14-6,156398-76-4
1,3-dimethyluracil

: 1613622-54-0
5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-methyltetrahydrofuran / 0.08 h / 30 °C / Inert atmosphere

1.2: 1.25 h / 0 - 5 °C / Inert atmosphere

2.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydride / mineral oil; tetrahydrofuran / 18 h

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: barium(II) hydroxide; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride / water; acetic acid butyl ester / 0.5 h / 80 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 60 °C

With n-butyllithium; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; tetrabutyl ammonium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; mineral oil; 4.1: |Suzuki Coupling;