(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Base Information

Chemical Name:(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
CAS No.:1613622-53-9
Molecular Formula:C₂₀H₂₂FN₃O₄
Molecular Weight:387.411
Hs Code.:

Synonyms:(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

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Chemical Property of (R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

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Technology Process of (R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

There total 7 articles about (R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613622-54-0
5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 156925-79-0
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate

: 1613622-53-9
(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: 5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione; With dibenzo-18-crown-6; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h;

[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3.08h;

Reference yield:

: 1613623-85-0
5-(3-fluorophenyl)-1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613622-53-9
(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 60 °C

2.1: dibenzo-18-crown-6; sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

2.2: 3.08 h / 0 - 20 °C

With dibenzo-18-crown-6; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1613622-53-9
(R)-6-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: barium(II) hydroxide; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride / water; acetic acid butyl ester / 0.5 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 60 °C

3.1: dibenzo-18-crown-6; sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

3.2: 3.08 h / 0 - 20 °C

With dibenzo-18-crown-6; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; tetrabutyl ammonium fluoride; sodium hydride; barium(II) hydroxide; In tetrahydrofuran; acetic acid butyl ester; water; N,N-dimethyl-formamide; mineral oil; 1.1: |Suzuki Coupling;