(S)-(-)-2--5-methoxytetralin

Base Information

• Chemical Name: (S)-(-)-2--5-methoxytetralin
• CAS No.: 136316-06-8
• Molecular Formula: C₂₂H₂₈N₂O₃
• Molecular Weight: 368.476
• Mol file: 136316-06-8.mol

Synonyms:(S)-(-)-2--5-methoxytetralin

Chemical Property of (S)-(-)-2--5-methoxytetralin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-(-)-2--5-methoxytetralin

There total 5 articles about (S)-(-)-2--5-methoxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-2-tetralone (32940-15-1) → (S)-(-)-2--5-methoxytetralin (136316-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) p-TsOH, 2.) H₂ / 2.) PtO₂ / 1.) toluene, reflux, 2 h, 2.) EtOH, 32 psi, 1 h

4: 5percent aq. NaOH / CH₂Cl₂ / 0.17 h / 25 °C

5: BH₃ / tetrahydrofuran / 2 h / Heating

With sodium hydroxide; borane; hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00115a012

Reference yield:

N-((S)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-2-(4-nitro-phenyl)-N-propyl-acetamide (136247-11-5) → (S)-(-)-2--5-methoxytetralin (136316-06-8)

Guidance literature:

With borane; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00115a012

Reference yield:

2-(N-benzylamino)-5-methoxytetralin (136247-07-9) → (S)-(-)-2--5-methoxytetralin (136316-06-8)

Guidance literature:

Multi-step reaction with 4 steps

3: 5percent aq. NaOH / CH₂Cl₂ / 0.17 h / 25 °C

4: BH₃ / tetrahydrofuran / 2 h / Heating

With sodium hydroxide; borane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00115a012

upstream raw materials:

N-((S)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-2-(4-nitro-phenyl)-N-propyl-acetamide

5-methoxy-2-tetralone

2-(N-benzylamino)-5-methoxytetralin

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

Downstream raw materials:

(S)-(-)-2--5-hydroxytetralin