N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Base Information

Chemical Name:N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
CAS No.:136247-07-9
Molecular Formula:C18H21NO
Molecular Weight:267.371
Hs Code.:
ChEMBL ID:CHEMBL1197043
DSSTox Substance ID:DTXSID10483986
Mol file:136247-07-9.mol

Synonyms:136247-07-9;N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)- 2-Naphthalenamine (Rotigotine);1,2,3,4-Tetrahydro-5-methoxy-N-(phenylmethyl)-2-naphthalenamine;SCHEMBL338733;CHEMBL1197043;SCHEMBL15474018;DTXSID10483986;OZFLGQHJVWSALN-UHFFFAOYSA-N;(R)-N-Benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;MFCD11110967;MFCD11110968;AKOS015910559;58349-20-5;SY347142;SY347143;SY347144;WS-01075;D85472;Z1857236671;(S)-N-Benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine formate;N-Benzyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)amine

Suppliers and Price of N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 18 raw suppliers

Chemical Property of N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Chemical Property:

Vapor Pressure:2.07E-07mmHg at 25°C
Refractive Index:1.593
Boiling Point:424.4 °C at 760 mmHg
Flash Point:176.6 °C
PSA：21.26000
Density:1.09 g/cm³
LogP:3.73320
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:267.162314293
Heavy Atom Count:20
Complexity:287

Purity/Quality:: ≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C1CCC(C2)NCC3=CC=CC=C3

Technology Process of N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

There total 5 articles about N-benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 32940-15-1
5-methoxy-2-tetralone

: 100-46-9
benzylamine

: 136247-07-9
2-(N-benzylamino)-5-methoxytetralin

Guidance literature:: 5-methoxy-2-tetralone; benzylamine; With acetic acid; In dichloromethane; at 20 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 15.5h;

With water; sodium hydrogencarbonate; In dichloromethane; at 0 ℃; for 0.25h; pH=8.0;

Reference yield:

: Benzyl-[5-methoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

: 136247-07-9
2-(N-benzylamino)-5-methoxytetralin

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; for 2.5h; under 1520 Torr;
DOI:10.1021/jm00072a008

Reference yield:

: 32940-15-1
5-methoxy-2-tetralone

: 136247-07-9
2-(N-benzylamino)-5-methoxytetralin

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH*H₂O / benzene / 17 h / Heating

2: H₂ / PtO₂ / ethanol / 2.5 h / 1520 Torr

With hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide; In ethanol; benzene;
DOI:10.1021/jm00072a008