4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Base Information

Chemical Name:4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide
CAS No.:1443021-97-3
Molecular Formula:C₃₂H₂₅ClFN₃O₄S
Molecular Weight:602.086
Hs Code.:

Synonyms:4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

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Chemical Property of 4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

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Technology Process of 4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

There total 6 articles about 4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 4-(4-(3-(4-chlorophenyl)-3-oxoprop-1-enyl)-3-p-tolyl-1Hpyrazol-1-yl)benzenesulfonamide

: 459-57-4
4-fluorobenzaldehyde

: 1443021-97-3
4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: With potassium cyanide; In N,N-dimethyl-formamide; at 30 - 35 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 1443021-97-3
4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / ethanol / 24 h / 20 °C

2: trichlorophosphate / Reflux

3: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

4: sodium hydroxide / ethanol; water / 24 h / 20 °C

5: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

With methanol; potassium cyanide; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 4: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

: 1135952-94-1
C₂₀H₂₀N₄O₃S

: 1443021-97-3
4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

2: sodium hydroxide / ethanol; water / 24 h / 20 °C

3: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

With methanol; potassium cyanide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.03.005