5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

Base Information

Chemical Name:5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol
CAS No.:129823-18-3
Molecular Formula:C₁₆H₁₅Cl₂NO₃
Molecular Weight:340.206
Hs Code.:

Synonyms:5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

Chemical Property:

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Technology Process of 5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

There total 4 articles about 5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 18637-83-7
1,1'-oxalyldiimidazole

: 129823-18-3
5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1121-46-6
2-Furan-2-yl-ethylamine

: 129823-18-3
5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl / 1.) ether, 2.) acetonitrile, 23 deg C, 3 h

2: 76 percent / LiAlH₄ / tetrahydrofuran / 3 h / 23 °C

3: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, 23 deg C, 30 min, 2.) CH₂Cl₂, 23 deg C, 20 h

With hydrogenchloride; lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1021/jm00040a004

Reference yield:

: methyl 4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-carboxylate hydrochloride

: 129823-18-3
5-<(3,4-dichlorophenyl)acetyl>-4,5,6,7-tetrahydrofuro<3,2-c>pyridine-4-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / LiAlH₄ / tetrahydrofuran / 3 h / 23 °C

2: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, 23 deg C, 30 min, 2.) CH₂Cl₂, 23 deg C, 20 h

With lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1021/jm00040a004