rac-ethyl 2-(4-nitrobenzamido)propanoate

Base Information

• Chemical Name: rac-ethyl 2-(4-nitrobenzamido)propanoate
• CAS No.: 76765-75-8
• Molecular Formula: C₁₂H₁₄N₂O₅
• Molecular Weight: 266.254

Synonyms:rac-ethyl 2-(4-nitrobenzamido)propanoate

Chemical Property of rac-ethyl 2-(4-nitrobenzamido)propanoate

Chemical Property:

Purity/Quality:

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Technology Process of rac-ethyl 2-(4-nitrobenzamido)propanoate

There total 2 articles about rac-ethyl 2-(4-nitrobenzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

DL-alanine ethyl ester hydrochloride (617-27-6) + 4-nitro-benzoyl chloride (122-04-3) → rac-ethyl 2-(4-nitrobenzamido)propanoate (76765-75-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201202455

Reference yield: 41.0%

(S)-alanine ethyl ester hydrochloride (1115-59-9) + 4-nitro-benzoyl chloride (122-04-3) → ethyl N-(4-nitrobenzoyl)-L-alaninate (76765-75-8)

Guidance literature:

With pyridine; In toluene; 1.) 0 deg C, 30 min, 2.) RT, 1 h;

DOI:10.1021/jm00156a033

Reference yield: 85.0%

ethyl N-(4-nitrobenzoyl)-L-alaninate (76765-75-8) → ethyl N-(4-aminobenzoyl)-L-alaninate (76765-77-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;

DOI:10.1021/jm00156a033

upstream raw materials:

DL-alanine ethyl ester hydrochloride

4-nitro-benzoyl chloride

(S)-alanine ethyl ester hydrochloride

Downstream raw materials:

(R)-4-methyl-2-(4-nitrophenyl)-4-((R)-3-oxo-1-phenylbutyl)oxazol-5(4H)-one

rac-2-(4-nitrobenzamido)propanoic acid

rac-4-methyl-2-(4-nitrophenyl)oxazol-5(4H)-one

ethyl N-(4-aminobenzoyl)-L-alaninate

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