(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

Base Information

Chemical Name:(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate
CAS No.:1201554-50-8
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

Chemical Property:

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Technology Process of (2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

There total 1 articles about (2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1254708-93-4
(2R,3S)-tert-butyl 2-(benzyloxy)-3-(4-methoxyphenylamino)-3-phenylpropanoate

: 1201554-50-8
(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 35 ℃; for 12h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/jo101559p

Reference yield: 100.0%

: 1201554-50-8
(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1201554-52-0
(2R,3S)-tert-butyl 2-(tert-butyldimethylsilyloxy)-3-(4-methoxyphenylamino)-3-phenylpropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1021/jo101559p

Reference yield:

: 1201554-50-8
(2R,3S)-tert-butyl 2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1201554-54-2
C₂₆H₃₇NO₄Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

2.1: ammonium cerium (IV) nitrate / acetonitrile / 1 h / 0 °C

2.2: 0.25 h / 20 °C

With ammonium cerium (IV) nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1039/c9ob02149c