(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

Base Information

Chemical Name:(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol
CAS No.:380414-69-7
Molecular Formula:C₃₆H₄₉NO₅
Molecular Weight:575.789
Hs Code.:

Synonyms:(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

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Chemical Property of (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

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Technology Process of (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

There total 12 articles about (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 97664-54-5
6-(4-phenylbutoxy)hexanal

: 380414-68-6
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol

: 380414-69-7
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

Guidance literature:: 6-(4-phenylbutoxy)hexanal; (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol; With (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid; In dichloromethane;

With resin-NMe₃⁽¹⁺⁾*NaCO₃^(1-); In dichloromethane; Further stages.;
DOI:10.1021/ol020128g

Reference yield:

: 102293-80-1
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

: 380414-69-7
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / i-Pr₂NEt / tetrahydrofuran / 4 h

2: 76 percent / CaCl₂*2H₂O; NaBH₄ / methanol / 2 h / 0 °C

3: 87 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 18 h

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; calcium chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b207068p

Reference yield:

: 3360-41-6
4-phenyl-butan-1-ol

: 380414-69-7
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: resin-DMAP / CH₂Cl₂

2.1: NaH / toluene / 80 °C

3.1: alumina-supported pyridinium chlorochromate / CH₂Cl₂

4.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH₂Cl₂

4.2: 98 percent / resin-NMe₃⁽¹⁺⁾*NaCO₃^(1-) / CH₂Cl₂

With pyridinium chlorochromate absorbed on neutral alumina; (polystyrylmethyl)trimethylammonium cyanoborohydride; resin-DMAP; sodium hydride; acetic acid; In dichloromethane; toluene;
DOI:10.1021/ol020128g