2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester

Base Information

• Chemical Name: 2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester
• CAS No.: 916811-64-8
• Molecular Formula: C₁₇H₂₂N₂O₆
• Molecular Weight: 350.371
• Mol file: 916811-64-8.mol

Synonyms:2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester

Chemical Property of 2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester

There total 1 articles about 2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Allyl acetate (591-87-7) + 2-carbomethoxyaniline (134-20-3) + ethyl iodoacetae (623-48-3) → 2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester (916811-64-8)

Guidance literature:

2-carbomethoxyaniline; With sulfuric acid; sodium nitrite; In water; Cooling;

Allyl acetate; ethyl iodoacetae; In methanol; water; Cooling;

With titanium(III) chloride; In methanol; water; at 0 ℃;

DOI:10.1002/ejoc.200600528

Reference yield: 79.0%

2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester (916811-64-8) → 4-acetylamino-5-hydroxypentanoic acid ethyl ester + 2-carbomethoxyaniline (134-20-3)

Guidance literature:

With hydrogen; nickel; In methanol; for 3h; under 37503 Torr;

DOI:10.1002/ejoc.200600528

Reference yield:

2-(1-acetoxymethyl-3-ethoxycarbonylpropylazo)benzoic acid methyl ester (916811-64-8) → 2-(3-cyano-1-hydroxymethyl-1-methylpropylazo)benzoic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / Raney-Ni / methanol / 3 h / 37503 Torr

2.1: NaNO₂; sulfuric acid / H₂O / Cooling

2.2: H₂O; methanol / Cooling

2.3: 68 percent / titanium(III) chloride / H₂O; methanol / 0 °C

With sulfuric acid; hydrogen; sodium nitrite; nickel; In methanol; water;

DOI:10.1002/ejoc.200600528

upstream raw materials:

Allyl acetate

2-carbomethoxyaniline

ethyl iodoacetae

Downstream raw materials:

2-carbomethoxyaniline

Refernces