4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Base Information

Chemical Name:4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester
CAS No.:860771-25-1
Molecular Formula:C₂₂H₂₇N₅O₄
Molecular Weight:425.487
Hs Code.:

4-[3-(2,4-diamino-5-methyl-pyrido[2,3-<i>d</i>]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Synonyms:4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Suppliers and Price of 4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

There total 10 articles about 4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860771-20-6
2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

: 860771-25-1
4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18 g / H₂ / Pd/C / ethanol / 3 h / 1034.3 Torr

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / Heating

3.2: n-BuNH₂ / CH₂Cl₂ / 1.5 h / Heating

4.1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h

5.1: 90 mg / NaOEt / dimethylsulfoxide / 20 °C

With palladium on activated charcoal; oxalyl dichloride; hydrogen; sodium ethanolate; sodium formate; N,N-dimethyl-formamide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm0581718

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 860771-25-1
4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

2.1: 18 g / H₂ / Pd/C / ethanol / 3 h / 1034.3 Torr

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / Heating

4.2: n-BuNH₂ / CH₂Cl₂ / 1.5 h / Heating

5.1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h

6.1: 90 mg / NaOEt / dimethylsulfoxide / 20 °C

With piperidine; palladium on activated charcoal; oxalyl dichloride; hydrogen; sodium ethanolate; sodium formate; acetic acid; N,N-dimethyl-formamide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 2-methoxy-ethanol; cyclohexane; dimethyl sulfoxide; toluene; 1.1: Knoevenagel reaction;
DOI:10.1021/jm0581718

Reference yield:

: 22159-41-7
methyl 4-methoxyphenyl carbonate

: 860771-25-1
4-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: TiCl₄ / CH₂Cl₂ / 0 - 20 °C

1.2: 8.76 g / aq. HCl / CH₂Cl₂

2.1: NaOMe / methanol / 0.5 h

3.1: 39 g / dimethylformamide / 3 h

4.1: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

5.1: 18 g / H₂ / Pd/C / ethanol / 3 h / 1034.3 Torr

6.1: 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

7.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / Heating

7.2: n-BuNH₂ / CH₂Cl₂ / 1.5 h / Heating

8.1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h

9.1: 90 mg / NaOEt / dimethylsulfoxide / 20 °C

With piperidine; palladium on activated charcoal; oxalyl dichloride; hydrogen; sodium methylate; sodium ethanolate; sodium formate; titanium tetrachloride; acetic acid; N,N-dimethyl-formamide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; 2-methoxy-ethanol; cyclohexane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 4.1: Knoevenagel reaction;
DOI:10.1021/jm0581718