2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

Base Information

Chemical Name:2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester
CAS No.:860771-20-6
Molecular Formula:C₂₁H₂₂O₅
Molecular Weight:354.403
Hs Code.:

Synonyms:2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

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Chemical Property of 2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

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Technology Process of 2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

There total 6 articles about 2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22159-41-7
methyl 4-methoxyphenyl carbonate

: 860771-20-6
2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TiCl₄ / CH₂Cl₂ / 0 - 20 °C

1.2: 8.76 g / aq. HCl / CH₂Cl₂

2.1: NaOMe / methanol / 0.5 h

3.1: 39 g / dimethylformamide / 3 h

4.1: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

With piperidine; sodium methylate; titanium tetrachloride; acetic acid; In methanol; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; 4.1: Knoevenagel reaction;
DOI:10.1021/jm0581718

Reference yield:

: 100-39-0
benzyl bromide

: 860771-20-6
2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 39 g / dimethylformamide / 3 h

2: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

With piperidine; acetic acid; In cyclohexane; N,N-dimethyl-formamide; toluene; 2: Knoevenagel reaction;
DOI:10.1021/jm0581718

Reference yield:

: 132638-49-4
2-methoxy-5-(methoxycarbonyloxy)benzaldehyde

: 860771-20-6
2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOMe / methanol / 0.5 h

2: 39 g / dimethylformamide / 3 h

3: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

With piperidine; sodium methylate; acetic acid; In methanol; cyclohexane; N,N-dimethyl-formamide; toluene; 3: Knoevenagel reaction;
DOI:10.1021/jm0581718