1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Base Information

Chemical Name:1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol
CAS No.:50830-38-1
Molecular Formula:C₂₈H₂₅ClF₅NO₂
Molecular Weight:537.957
Hs Code.:

Synonyms:1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Suppliers and Price of 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

There total 8 articles about 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 21928-50-7
4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol

: 20662-52-6
4,4-bis(4-fluorophenyl)butanoic acid

: 50830-38-1
1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Guidance literature:: 4,4-bis(4-fluorophenyl)butanoic acid; With chloroformic acid ethyl ester; triethylamine; In chloroform; at 0 ℃; for 1h;

4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol; In chloroform; at 40 ℃; for 6h;

Reference yield:

: 51787-96-3
5-(4-fluorophenyl)dihydrofuran-2(3H)-one

: 50830-38-1
1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 3 h / 15 °C

2.1: triethylamine; chloroformic acid ethyl ester / chloroform / 1 h / 0 °C

2.2: 6 h / 40 °C

With aluminum (III) chloride; chloroformic acid ethyl ester; triethylamine; In chloroform; 1.1: |Friedel-Crafts Alkylation;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 50830-38-1
1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol

Guidance literature:: Multi-step reaction with 3 steps

1.1: calcium chloride; magnesium / diethyl ether / 20 °C / Autoclave

1.2: 1 h / Reflux

1.3: 1.5 h

2.1: sodium hydroxide / ethanol / 3.5 h / Reflux

3.1: triethylamine; chloroformic acid ethyl ester / chloroform / 1 h / 0 °C

3.2: 6 h / 40 °C

With chloroformic acid ethyl ester; magnesium; triethylamine; calcium chloride; sodium hydroxide; In diethyl ether; ethanol; chloroform;