Chemical Property of Penfluridol
Chemical Property:
- Appearance/Colour:white powder
- Vapor Pressure:1.17E-14mmHg at 25°C
- Melting Point:105-107 °C
- Refractive Index:1.552
- Boiling Point:587.7 °C at 760 mmHg
- PKA:13.49±0.20(Predicted)
- Flash Point:309.2 °C
- PSA：23.47000
- Density:1.29 g/cm3
- LogP:7.47060
- Storage Temp.:2-8°C
- Solubility.:H2O: insoluble
- XLogP3:7.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:523.1701330
- Heavy Atom Count:36
- Complexity:647
- Purity/Quality:
-
99%, *data from raw suppliers
Penfluridol >98.0%(T) *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
-
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
- Recent EU Clinical Trials:Effectiveness of penfluridol (oral long acting neuroleptic) as compared to second generation oral neuroleptics in psychotic disorder patients: an open label randomized controlled trial.
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Uses
antineoplastic In terms of pharmacological action, penfluridol is similar to pimozide; however, it is significantly longer lasting, which is connected to the slow metabolism of the drug.
Penfluridol is used as a supportive therapy in ambulatory settings for patients suffering
from schizophrenia as well as patients with paranoid, psychotic, and neuroleptic conditions. Penfluridol has been used as an antipsychotic agent:to study its antimetastatic effect on triple-negative breast cancer cellsto study its effects on the growth of glioblastoma cell lines,to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)
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Therapeutic Function
Antipsychotic
