N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide
CAS No.:1300117-58-1
Molecular Formula:C₂₁H₂₃NO₃S
Molecular Weight:369.485
Hs Code.:

Synonyms:N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

Suppliers and Price of N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

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Technology Process of N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

There total 1 articles about N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: N-benzyl-N-((E)-3-hydroxybut-1-enyl)-4-methylbenzenesulfonamide

: 106-96-7
propargyl bromide

: 1300117-58-1
N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; toluene; at 20 ℃; for 4h;
DOI:10.1002/chem.201003265

Reference yield: 78.0%

: 75-77-4
chloro-trimethyl-silane

: 1300117-58-1
N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

: 1029537-41-4
N-benzyl-N-{(E)-3-[(3-trimethylsilylprop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

Guidance literature:: N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1002/chem.201003265

Reference yield:

: 1300117-58-1
N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide

: C₂₂H₂₇NO₄SiS

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; citric acid / water; tert-butyl alcohol / 60 h / 20 °C

4.1: sodium periodate / tetrahydrofuran; water / 0.5 h / 20 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; 4-methylmorpholine N-oxide; citric acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; tert-butyl alcohol; 2.1: Wittig rearrangement;
DOI:10.1002/chem.201003265