3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

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Chemical Name:3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide
CAS No.:1352082-78-0
Molecular Formula:C₃₄H₃₃N₅O₂
Molecular Weight:543.668
Hs Code.:

Synonyms:3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

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Chemical Property of 3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

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Technology Process of 3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

There total 12 articles about 3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1352082-73-5
3-cyclohexyl-2-phenyl-2H-indazole-6-carboxylic acid

: 1352083-16-9
N-[4-(pyridin-4-yl)phenyl]-D-alaninamide hydrochloride

: 1352082-78-0
3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1352082-78-0
3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1352082-78-0
3-cyclohexyl-N-[(2R)-1-oxo-1-{[4-(pyridin-4-yl)phenyl]amino}propan-2-yl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;