4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Base Information

Chemical Name:4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole
CAS No.:200418-13-9
Molecular Formula:C₂₉H₂₁FN₄O
Molecular Weight:460.51
Hs Code.:

Synonyms:4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

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Technology Process of 4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

There total 5 articles about 4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 144-55-8
sodium hydrogencarbonate

: 170498-28-9
1-N,N-dimethylcarbamoyl-4-bromo-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

: 200418-13-9
4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 200418-13-9
4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH / 1.) THF, RT, 15 min, 2.) THF, RT, 4 h

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 1.) NaBr, 2.) DMPU / 1.) THF, RT, 1 h, 2.) THF, RT, 3 h

4: 111 mg / tetrakis(triphenylphosphine)palladium⁽⁰⁾, aq. NaHCO₃ / dimethylformamide / a) 90 deg C, 4 h, b) 40 deg C, 48 h, c) 115 deg C, 4 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium hydrogencarbonate; sodium bromide; In N,N-dimethyl-formamide;
DOI:10.1021/jm970389+

Reference yield:

: 200418-18-4
4-Bromo-indole-1-carboxylic acid dimethylamide

: 200418-13-9
4-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

2: 1.) NaBr, 2.) DMPU / 1.) THF, RT, 1 h, 2.) THF, RT, 3 h

3: 111 mg / tetrakis(triphenylphosphine)palladium⁽⁰⁾, aq. NaHCO₃ / dimethylformamide / a) 90 deg C, 4 h, b) 40 deg C, 48 h, c) 115 deg C, 4 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium hydrogencarbonate; sodium bromide; In N,N-dimethyl-formamide;
DOI:10.1021/jm970389+