2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone

Base Information

• Chemical Name: 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone
• CAS No.: 1180657-25-3
• Molecular Formula: C₁₈H₁₅NO₄S₂
• Molecular Weight: 373.453

Synonyms:2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone

Chemical Property of 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone

Chemical Property:

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Technology Process of 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone

There total 2 articles about 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

dipotassium 2-nitroethylene-1,1-dithiolate (25963-52-4) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + α-bromoacetophenone (70-11-1) → 2-[(3-nitro-4-phenylthiophen-2-yl)thio]-1-phenylethanone (1180657-19-5) + 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone (1180657-25-3) + 2,2'-[(2-nitroethene-1,1-diyl)dithiodiyl]bis(1-phenylethanone) (19420-00-9)

Guidance literature:

With tetrabutylammomium bromide; In toluene; at 0 - 20 ℃;

DOI:10.1021/jo9008639

Reference yield: 68.0%

dipotassium 2-nitroethylene-1,1-dithiolate (25963-52-4) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) → 2-[(3-nitro-4-phenylthiophen-2-yl)thio]-1-phenylethanone (1180657-19-5) + 2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone (1180657-25-3)

Guidance literature:

With tetrabutylammomium bromide; In toluene; at 0 - 20 ℃; for 7h;

DOI:10.1021/jo9008639

Reference yield: 100.0%

2-[(4-hydroxy-3-nitro-4-phenyl-4,5-dihydrothiophen-2-yl)thio]-1-phenylethanone (1180657-25-3) → 2-[(3-nitro-4-phenylthiophen-2-yl)thio]-1-phenylethanone (1180657-19-5)

Guidance literature:

With toluene-4-sulfonic acid; Microwave irradiation;

DOI:10.1021/jo9008639

upstream raw materials:

dipotassium 2-nitroethylene-1,1-dithiolate

1-chloroacetophenone

α-bromoacetophenone

Downstream raw materials:

2-[(3-nitro-4-phenylthiophen-2-yl)thio]-1-phenylethanone

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