2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide

Base Information

• Chemical Name: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide
• CAS No.: 105199-58-4
• Molecular Formula: C₄₂H₂₈Cl₂N₄O₄S₂
• Molecular Weight: 787.747
• Mol file: 105199-58-4.mol

Synonyms:2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide

Chemical Property of 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide

There total 4 articles about 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(4-Chloro-phenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (105199-63-1) → 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide (105199-58-4)

Guidance literature:

With bromomalononitrile; sodium ethanolate; In ethanol; for 1h; Reflux;

Reference yield: 67.0%

6-phenyl-4-(p-chlorophenyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridine-2(3H)-thione (105199-53-9) → 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide (105199-58-4)

Guidance literature:

With nitrosylsulfuric acid; In acetic acid; at 0 ℃; for 1h;

Reference yield:

Sodium; (4R,5S,6R)-4-(4-chloro-phenyl)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate (105199-43-7) → 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide (105199-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetic acid / H₂O

2: 67 percent / nitrosylsulfuric acid / acetic acid / 1 h / 0 °C

With nitrosylsulfuric acid; acetic acid; In water; acetic acid;

upstream raw materials:

4-(4-Chloro-phenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

6-phenyl-4-(p-chlorophenyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridine-2(3H)-thione

Sodium; (4R,5S,6R)-4-(4-chloro-phenyl)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

(Z)-ethyl 2-benzoyl-3-(4'-chlorophenyl)-3-propenoate

Downstream raw materials:

4-(4-Chloro-phenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester