{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

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Chemical Name:{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane
CAS No.:900159-57-1
Molecular Formula:C₂₇H₄₈O₃S₂Si
Molecular Weight:512.894
Hs Code.:

Synonyms:{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

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Chemical Property of {(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

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Technology Process of {(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

There total 8 articles about {(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 159751-61-8
((S)-3-Iodo-2-methyl-propoxymethoxymethyl)-benzene

: 503620-25-5
tert-butyl-(1-[1,3]dithian-2-ylmethyl-butoxy)-dimethyl-silane

: 900159-57-1
{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

Guidance literature:: tert-butyl-(1-[1,3]dithian-2-ylmethyl-butoxy)-dimethyl-silane; With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; In tetrahydrofuran; for 0.5h;

((S)-3-Iodo-2-methyl-propoxymethoxymethyl)-benzene; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jo0605086

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 900159-57-1
{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / H₂ / (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II) / methanol / 100 °C / 15200 Torr

2.1: 92 percent / imidazole / dimethylformamide / 6 h / 20 °C

3.1: 91 percent / DIBAL-H / CH₂Cl₂; toluene / 2.5 h / -78 °C

4.1: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

5.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

6.1: t-BuLi; HMPA / tetrahydrofuran / 0.5 h

6.2: 83 percent / tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; hydrogen; tert.-butyl lithium; diisobutylaluminium hydride; (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II); In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0605086

Reference yield:

: 2305-25-1,88496-71-3,123807-92-1,84314-29-4
ethyl (R)-3-hydroxyhexanoate

: 900159-57-1
{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / imidazole / dimethylformamide / 6 h / 20 °C

2.1: 91 percent / DIBAL-H / CH₂Cl₂; toluene / 2.5 h / -78 °C

3.1: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

4.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

5.1: t-BuLi; HMPA / tetrahydrofuran / 0.5 h

5.2: 83 percent / tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; tert.-butyl lithium; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0605086