(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

Base Information

Chemical Name:(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one
CAS No.:900159-58-2
Molecular Formula:C₂₄H₄₂O₄Si
Molecular Weight:422.681
Hs Code.:

Synonyms:(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

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Chemical Property of (2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

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Technology Process of (2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

There total 10 articles about (2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 900159-57-1
{(R)-1-[2-((R)-3-Benzyloxymethoxy-2-methyl-propyl)-[1,3]dithian-2-ylmethyl]-butoxy}-tert-butyl-dimethyl-silane

: 900159-58-2
(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

Guidance literature:: With water; iodine; sodium hydrogencarbonate; In acetone; for 1h;
DOI:10.1021/jo0605086

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 900159-58-2
(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 92 percent / H₂ / (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II) / methanol / 100 °C / 15200 Torr

2.1: 92 percent / imidazole / dimethylformamide / 6 h / 20 °C

3.1: 91 percent / DIBAL-H / CH₂Cl₂; toluene / 2.5 h / -78 °C

4.1: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

5.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

6.1: t-BuLi; HMPA / tetrahydrofuran / 0.5 h

6.2: 83 percent / tetrahydrofuran / 1 h / -78 °C

7.1: 83 percent / NaHCO₃; I₂; water / acetone / 1 h

With 1H-imidazole; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; water; hydrogen; iodine; tert.-butyl lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II); In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jo0605086

Reference yield:

: 2305-25-1,88496-71-3,123807-92-1,84314-29-4
ethyl (R)-3-hydroxyhexanoate

: 900159-58-2
(2R,6R)-1-Benzyloxymethoxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-nonan-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / imidazole / dimethylformamide / 6 h / 20 °C

2.1: 91 percent / DIBAL-H / CH₂Cl₂; toluene / 2.5 h / -78 °C

3.1: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

4.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

5.1: t-BuLi; HMPA / tetrahydrofuran / 0.5 h

5.2: 83 percent / tetrahydrofuran / 1 h / -78 °C

6.1: 83 percent / NaHCO₃; I₂; water / acetone / 1 h

With 1H-imidazole; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; water; iodine; tert.-butyl lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jo0605086