3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether

Base Information

• Chemical Name: 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether
• CAS No.: 208105-74-2
• Molecular Formula: C₂₅H₂₉N₄OP
• Molecular Weight: 432.505
• Mol file: 208105-74-2.mol

Synonyms:3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether

Chemical Property of 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether

There total 3 articles about 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl iodide (75-03-6) + 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propan-1-ol (208105-69-5) → 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether (208105-74-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; 1.) 0 deg C, 20 min; 2.) RT;

DOI:10.1002/(sici)1099-0682(199806)1998:6<675::aid-ejic675>3.0.co;2-m

Reference yield:

Methanesulfonic acid 3-bromomethyl-oxetan-3-ylmethyl ester (168284-66-0) → 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether (208105-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / 1.) KOtBu / tetrahydrofuran / 1.) a.) 0 deg C; b.) RT, 20 min; 2.) reflux, 4 h

2: 81 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 1.) a.) 0 deg C; b.) RT, 20 min; 2.) 0 deg C up to RT

3: 91 percent / 1.) KOtBu / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) RT

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane;

DOI:10.1002/(sici)1099-0682(199806)1998:6<675::aid-ejic675>3.0.co;2-m

Reference yield:

3,3-bis(pyrazol-1-ylmethyl)oxetane (208105-64-0) → 3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propylethyl ether (208105-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 1.) a.) 0 deg C; b.) RT, 20 min; 2.) 0 deg C up to RT

2: 91 percent / 1.) KOtBu / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) RT

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane;

DOI:10.1002/(sici)1099-0682(199806)1998:6<675::aid-ejic675>3.0.co;2-m

upstream raw materials:

ethyl iodide

3-(diphenylphosphanyl)-2,2-bis(pyrazol-1-yl-methyl)propan-1-ol

Methanesulfonic acid 3-bromomethyl-oxetan-3-ylmethyl ester

3,3-bis(pyrazol-1-ylmethyl)oxetane

Downstream raw materials:

CH₂P(C₆H₅)2C[CH₂(C₃H₃N₂)]2CH₂OC₂H₅NiBr₂

[CH₂P(C₆H₅)2C[CH₂(C₃H₃N₂)]2CH₂OC₂H₅NiBr₂]2

C₂H₅OCH₂C[CH₂(C₃H₃N₂)]2CH₂P(C₆H₅)2Pd(C₃H₅)⁽¹⁺⁾*PF₆^(1-)=C₂H₅OCH₂C[CH₂(C₃H₃N₂)]2CH₂P(C₆H₅)2Pd(C₃H₅)PF₆