(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

Base Information

Chemical Name:(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine
CAS No.:1033719-19-5
Molecular Formula:C₁₄H₁₄Cl₂FN₃
Molecular Weight:314.19
Hs Code.:

Synonyms:(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

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Chemical Property of (1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

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Technology Process of (1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

There total 13 articles about (1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-chloro-5-[(3R,4S)-4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-1,2,5-thiadiazolidin-3-yl]pyridine

: 1033719-19-5
(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

Guidance literature:: With ethylenediamine; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield: 45.0%

: (1R*,2S*)-1-(9-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

: 1033719-19-5
(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

Guidance literature:: (1R*,2S*)-1-(9-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine; With L-Tartaric acid; In ethanol; at 110 ℃; for 0.5h; Reflux;

With sodium hydroxide; In ethanol; water;

Reference yield:

: 55676-22-7
3-acetyl-6-chloropyridine

: 1033719-19-5
(1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine

Guidance literature:: Multi-step reaction with 11 steps

1.1: ammonium hydroxide; ammonium chloride / methanol / 72 h / 20 °C

1.2: 2 h / Reflux; Cooling with ice

2.1: triethylamine / tetrahydrofuran / 36 h / Reflux

2.2: Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.2: Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

5.1: tetrahydrofuran / 1 h / Cooling with ice

6.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Cooling with ice

8.1: SULFAMIDE; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 42 h / 95 °C / Molecular sieve

9.1: sodium tetrahydroborate / ethanol / 2 h / Cooling with ice

10.1: ethylenediamine / 1,4-dioxane / 18 h / 100 °C

11.1: L-Tartaric acid / ethanol / 0.5 h / 110 °C / Reflux

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; L-Tartaric acid; sulfur trioxide pyridine complex; acetic anhydride; SULFAMIDE; ammonium chloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; ethylenediamine; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide;