tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate
CAS No.:1199793-09-3
Molecular Formula:C₁₉H₂₁Cl₂FN₂O₃
Molecular Weight:415.292
Hs Code.:

Synonyms:tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

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Chemical Property of tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

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Technology Process of tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

There total 5 articles about tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 170793-00-7
4-chloro-3-fluorophenylmagnesium bromide

: 1199793-08-2
tert-butyl [1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl] carbamate

: 1199793-09-3
tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

Guidance literature:: 4-chloro-3-fluorophenylmagnesium bromide; tert-butyl [1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl] carbamate; In tetrahydrofuran; for 1h; Cooling with ice;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 55676-22-7
3-acetyl-6-chloropyridine

: 1199793-09-3
tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide; ammonium chloride / methanol / 72 h / 20 °C

1.2: 2 h / Reflux; Cooling with ice

2.1: triethylamine / tetrahydrofuran / 36 h / Reflux

2.2: Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.2: Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

5.1: tetrahydrofuran / 1 h / Cooling with ice

With ammonium hydroxide; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 1199793-06-0
ethyl 2-amino-2-(6-chloropyridin-3-yl)propanoate

: 1199793-09-3
tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 36 h / Reflux

1.2: Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.2: Cooling with ice

3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

4.1: tetrahydrofuran / 1 h / Cooling with ice

With lithium aluminium tetrahydride; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;