(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

Base Information

Chemical Name:(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde
CAS No.:157555-32-3
Molecular Formula:C₁₃H₂₂O₃
Molecular Weight:226.316
Hs Code.:

Synonyms:(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

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Chemical Property of (R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

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Technology Process of (R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

There total 1 articles about (R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 87787-12-0
1-methyl-t-4-(2-tetrahydropyranyloxy)-r-1-cyclohexanemethanol

: 157555-32-3
(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

Guidance literature:: With pyridine; sulfur trioxide; triethylamine; In dimethyl sulfoxide; for 0.75h; Ambient temperature;
DOI:10.1021/jm00041a013

Reference yield: 100.0%

: 78055-64-8
(3-chlorobenzyl)phosphonic acid ethyl ester

: 157555-32-3
(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

: 157555-33-4
(R,S)-<1α,4β(E)>-2-<<4-<2-(3-chlorophenyl)ethenyl>-4-methylcyclohexyl>oxy>tetrahydro-2H-pyran

Guidance literature:: With sodium methylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1021/jm00041a013

Reference yield:

: 157555-32-3
(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

: 4-{2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-ethyl}-4-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaOMe / dimethylformamide / 0.25 h / 0 °C

2: 92 percent / Ni(dppp)Cl₂ / diethyl ether; tetrahydrofuran / 22 h / 31 °C

3: 79 percent / aq. acetic acid / tetrahydrofuran / 29 h / Ambient temperature

4: 87 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr / Ambient temperature

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); hydrogen; sodium methylate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a013