diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

Base Information

• Chemical Name: diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate
• CAS No.: 84454-07-9
• Molecular Formula: C₂₀H₂₈NO₅PS
• Molecular Weight: 425.486
• Mol file: 84454-07-9.mol

Synonyms:diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

Chemical Property of diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

There total 4 articles about diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diisopropyl hydrogenphosphonate (1809-20-7) + phenyl N-tosyl imine (51608-60-7) → diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate (84454-07-9)

Guidance literature:

With triethylamine; In toluene; Reflux; Inert atmosphere;

DOI:10.1002/adsc.201200516

Reference yield:

toluene-4-sulfonamide (70-55-3) → diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate (84454-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / toluene / 110 °C / Dean-Stark; Inert atmosphere

2: triethylamine / toluene / Reflux; Inert atmosphere

With boron trifluoride diethyl etherate; triethylamine; In toluene;

DOI:10.1002/adsc.201200516

Reference yield:

diisopropyl hydrogenphosphonate (1809-20-7) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate (84454-07-9)

Guidance literature:

With triethylamine; In toluene; for 24h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/acs.orglett.5b03664

upstream raw materials:

diisopropyl phosphite

N-(benzylidene)-p-methylbenzenesulfonamide

diisopropyl hydrogenphosphonate

phenyl N-tosyl imine

Downstream raw materials:

(E)-diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

(S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate