(S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

Base Information

• Chemical Name: (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate
• CAS No.: 1416426-76-0
• Molecular Formula: C₂₁H₂₇N₂O₅PS
• Molecular Weight: 450.496
• Mol file: 1416426-76-0.mol

Synonyms:(S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

Chemical Property of (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

There total 9 articles about (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Acetyl cyanide (631-57-2) + (E)-diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate (1416426-66-8) → (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate (1416426-76-0)

Guidance literature:

With 10,11-dihydrocinchonidine; In chloroform; at -45 ℃; Inert atmosphere;

DOI:10.1002/adsc.201200516

Reference yield: 80.0%

Acetyl cyanide (631-57-2) + (E)-diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate (1416426-66-8) → (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate (1416426-76-0) + (R)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

Guidance literature:

With qunidine; In chloroform; at -45 ℃; Inert atmosphere;

DOI:10.1002/adsc.201200516

Reference yield:

Acetyl cyanide (631-57-2) + diisopropyl (phenyl(tosylimino)methyl)phosphonate → (S)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate (1416426-76-0) + (R)-diisopropyl (cyano(4-methylphenylsulfonamido)(phenyl)methyl)phosphonate

Guidance literature:

With cinchona alkaloid; In chloroform; at 25 ℃; Reagent/catalyst; Optical yield = 80 %ee; enantioselective reaction;

DOI:10.1080/10426507.2018.1528258

upstream raw materials:

diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

phenyl N-tosyl imine

Acetyl cyanide

(E)-diisopropyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate