3,4,5-Trimethoxybenzoic Anhydride

Base Information

• Chemical Name: 3,4,5-Trimethoxybenzoic Anhydride
• CAS No.: 1719-88-6
• Molecular Formula: C20H22 O9
• Molecular Weight: 406.389
• Hs Code.: 2918990090
• European Community (EC) Number: 217-010-8
• NSC Number: 40557
• UNII: QFG37BUS5X
• DSSTox Substance ID: DTXSID40169185
• Nikkaji Number: J203.114K
• Wikidata: Q83038843
• Mol file: 1719-88-6.mol

Synonyms:3,4,5-Trimethoxybenzoic Anhydride;1719-88-6;(3,4,5-trimethoxybenzoyl) 3,4,5-trimethoxybenzoate;3,3',4,4',5,5'-Hexamethoxybenzoic anhydride;3,4,5-TrimethoxybenzoicAnhydride;QFG37BUS5X;EINECS 217-010-8;NSC-40557;NSC40557;UNII-QFG37BUS5X;SCHEMBL8148063;DTXSID40169185;3,4,5-trimethoxybenzoic anhy-dride;3,4,5-Trimethoxyphenyl anhydride #;MFCD00017155;NSC 40557;Bis(3,4,5-trimethoxybenzoic)anhydride;AS-61387;Benzoic acid, 3,4,5-trimethoxy-, anhydride;CS-0324202;FT-0614164;T1093;D92450;3,4,5-trimethoxybenzoyl 3,4,5-trimethoxybenzoate;A881898;BENZOIC ACID, 3,4,5-TRIMETHOXY-, 1,1'-ANHYDRIDE

Chemical Property of 3,4,5-Trimethoxybenzoic Anhydride

Chemical Property:

• Melting Point: 155°C
• Boiling Point: 573.5°Cat760mmHg
• Flash Point: 249.9°C
• PSA: 98.75000
• Density: 1.228g/cm³
• LogP: 2.73540
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 406.12638228
• Heavy Atom Count: 29
• Complexity: 466

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4,5-Trimethoxybenzoic Anhydride >95.0%(T) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)OC(=O)C2=CC(=C(C(=C2)OC)OC)OC

Technology Process of 3,4,5-Trimethoxybenzoic Anhydride

There total 8 articles about 3,4,5-Trimethoxybenzoic Anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Eudesmic acid (118-41-2) → 3,4,5-trimethoxybenzoic anhydride (1719-88-6)

Guidance literature:

With triethylamine; Phenyl N-phenylphosphoramidochloridate; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1055/s-1981-29391

Reference yield: 76.0%

(3,4,5-trimethoxyphenyl)methanol (3840-31-1) → 3,4,5-trimethoxybenzoic anhydride (1719-88-6)

Guidance literature:

With tert.-butylhydroperoxide; tetrabutyl phosphonium bromide; In water; chlorobenzene; at 80 ℃; for 3.5h; Sealed tube;

DOI:10.1055/s-0036-1590905

Reference yield: 60.0%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 3,4,5-trimethoxybenzoic anhydride (1719-88-6)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In toluene; for 0.75h; Heating;

DOI:10.1002/hc.20039

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

Eudesmic acid

ethylene glycol

dicyclohexyl-carbodiimide

Downstream raw materials:

5-hydroxy-3,6,7,8,3',4',5'-heptamethoxyflavone

5-hydroxy-3',4',5'-trimethoxyflavone

7-hydroxy-3,3',4',5,5',8-hexamethoxyflavone

3-methoxy-2-(3,4,5-trimethoxy-phenyl)-furo[2,3-h]chromen-4-one

Refernces

• 1、 Nuree, Yasin,Singha, Raju,Ghosh, Munmun,Roy, Pronay,Ray, Jayanta K.. "Cu(I) catalyzed synthesis of anhydrides from aldehydes via CDC-pathway at ambient temperature". . p. 1479 - 1482. Retrieved 2016.
• 2、 Adib, Mehdi,Pashazadeh, Rahim. "TBHP/ n -Bu 4 PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives". supporting information. p. 136 - 140. Retrieved 2017/12/27.