5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Base Information

Chemical Name:5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
CAS No.:131653-16-2
Molecular Formula:C₂₀H₂₂N₂O₆
Molecular Weight:386.404
Hs Code.:

Synonyms:5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

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Chemical Property of 5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

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Technology Process of 5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

There total 9 articles about 5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 131653-13-9
5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium; iodide

: 131653-16-2
5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.0833333h;

Reference yield:

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 131653-16-2
5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: acide nitrique fumant, anhydride acetique / -20 °C

2: 98.5 percent / aq. KOH / methanol / 0.5 h / Heating

3: SOCl₂, triethylamine / benzene / 3 h / Heating

4: triethylamine / diethyl ether

5: benzoate d'argent, triethylamine / diethyl ether; acetonitrile

6: Roblot F_., Hocquemiller R_., Cave A_., J_. Chem_. Research ⁽¹⁹⁸⁹⁾ (S) 344-345 (M) 2637-2651

7: 75 percent / CHCl₃ / Heating

8: 98 percent / NaBH₄ / methanol / 0.08 h

With potassium hydroxide; sodium tetrahydroborate; thionyl chloride; acide nitrique fumant; benzoate d'argent; acetic anhydride; triethylamine; In methanol; diethyl ether; chloroform; acetonitrile; benzene;

Reference yield:

: 113884-71-2
Acide 2-nitro-3,5-dimethoxybenzoique

: 131653-16-2
5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂, triethylamine / benzene / 3 h / Heating

2: triethylamine / diethyl ether

3: benzoate d'argent, triethylamine / diethyl ether; acetonitrile

4: Roblot F_., Hocquemiller R_., Cave A_., J_. Chem_. Research ⁽¹⁹⁸⁹⁾ (S) 344-345 (M) 2637-2651

5: 75 percent / CHCl₃ / Heating

6: 98 percent / NaBH₄ / methanol / 0.08 h

With sodium tetrahydroborate; thionyl chloride; benzoate d'argent; triethylamine; In methanol; diethyl ether; chloroform; acetonitrile; benzene;