N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

Base Information

Chemical Name:N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide
CAS No.:150681-17-7
Molecular Formula:C₂₅H₂₅N₃O₂
Molecular Weight:399.492
Hs Code.:

Synonyms:N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

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Chemical Property of N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

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Technology Process of N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

There total 6 articles about N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 137976-95-5
5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine

: 150681-17-7
N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; for 5h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm960133o

Reference yield:

: 1127-74-8
1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one

: 150681-17-7
N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) hydroxylamine*HCl, 2.) pyridine / 1.) reflux, 2.5, 2.) RT, 3 h

5: 96 percent / H₂, acetic acid / PtO₂ / 5 h / 760 Torr / Ambient temperature

With pyridine; hydroxylamine hydrochloride; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960133o

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 150681-17-7
N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) hydroxylamine*HCl, 2.) pyridine / 1.) reflux, 2.5, 2.) RT, 3 h

5: 96 percent / H₂, acetic acid / PtO₂ / 5 h / 760 Torr / Ambient temperature

With pyridine; hydroxylamine hydrochloride; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960133o