(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

Base Information

Chemical Name:(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid
CAS No.:648864-03-3
Molecular Formula:C₂₅H₁₅Cl₃N₂O₄
Molecular Weight:513.764
Hs Code.:

Synonyms:(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

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Chemical Property of (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

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Technology Process of (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

There total 4 articles about (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 648869-43-6
5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazole-3-carbaldehyde

: 1878-65-5
3-chlorophenylacetic acid

: 648864-03-3
(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

Guidance literature:: With acetic anhydride; triethylamine; for 3h; Reflux;
DOI:10.1021/jo1017684

Reference yield: 67.0%

: C₂₆H₁₇Cl₃N₂O₄

: 648864-03-3
(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

: 872603-84-4
(Z)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid methyl ester

Guidance literature:: C₂₆H₁₇Cl₃N₂O₄; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; water; pH=4; stereoselective reaction;
DOI:10.1021/jo1017684