1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

Base Information

Chemical Name:1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol
CAS No.:1343415-03-1
Molecular Formula:C₂₁H₂₄O₄S
Molecular Weight:372.485
Hs Code.:

Synonyms:1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

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Chemical Property of 1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

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Technology Process of 1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

There total 4 articles about 1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1343414-81-2
C₂₀H₂₀O₄S

: 74-88-4
methyl iodide

: 1343415-03-1
1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

Guidance literature:: methyl iodide; With iodine; magnesium; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

C₂₀H₂₀O₄S; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.127

Reference yield:

: 20321-73-7
7-methoxy-2,2-dimethyl-4-chromanone

: 1343415-03-1
1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

3.1: iodine; magnesium / tetrahydrofuran / 25 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With iodine; sodium hydride; magnesium; trichlorophosphate; In tetrahydrofuran; 1.2: Vilsmeier-Haack-Arnold reaction;
DOI:10.1016/j.tetlet.2011.08.127

Reference yield:

: 15570-12-4
3-methoxybenzenethiol

: 1343415-03-1
1-(7-methoxy-4-(3-methoxyphenylthio)-2,2-dimethyl-2H-chromen-3-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: iodine; magnesium / tetrahydrofuran / 25 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With iodine; sodium hydride; magnesium; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2011.08.127