Technology Process of [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone
There total 10 articles about [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dimethyl sulfoxide;
at 20 ℃;
for 2h;
DOI:10.1016/j.tet.2011.01.029
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
3.2: 20 °C
4.1: propionic acid / toluene / 24 h / Reflux
5.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C
With
1H-imidazole; hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
2.2: 20 °C
3.1: propionic acid / toluene / 24 h / Reflux
4.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C
With
hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029