[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

Base Information

Chemical Name:[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone
CAS No.:1279707-73-1
Molecular Formula:C₃₃H₂₈N₂O₇S₂
Molecular Weight:628.727
Hs Code.:

Synonyms:[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

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Chemical Property of [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

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Technology Process of [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

There total 10 articles about [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1279707-72-0
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

: 1279707-73-1
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 1953-54-4
indol-5-ol

: 1279707-73-1
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

3.2: 20 °C

4.1: propionic acid / toluene / 24 h / Reflux

5.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 106792-38-5
5-(tert-butyl-dimethyl-silanyloxy)-1H-indole

: 1279707-73-1
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

2.2: 20 °C

3.1: propionic acid / toluene / 24 h / Reflux

4.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029