[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

Base Information

Chemical Name:[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol
CAS No.:1279707-72-0
Molecular Formula:C₃₃H₃₀N₂O₇S₂
Molecular Weight:630.742
Hs Code.:

Synonyms:[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

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Chemical Property of [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

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Technology Process of [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

There total 9 articles about [5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1279707-71-9
4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

: 74-88-4
methyl iodide

: 1279707-72-0
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 1953-54-4
indol-5-ol

: 1279707-72-0
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

3.2: 20 °C

4.1: propionic acid / toluene / 24 h / Reflux

5.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 106792-38-5
5-(tert-butyl-dimethyl-silanyloxy)-1H-indole

: 1279707-72-0
[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

2.2: 20 °C

3.1: propionic acid / toluene / 24 h / Reflux

4.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; dihydrogen peroxide; sodium hydride; potassium carbonate; propionic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029