N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

Base Information

Chemical Name:N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine
CAS No.:1372532-44-9
Molecular Formula:C₁₉H₁₈N₆O
Molecular Weight:346.392
Hs Code.:

N<sub>2</sub>-benzyl-N<sub>4</sub>-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

Synonyms:N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

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Chemical Property of N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

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Technology Process of N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

There total 2 articles about N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1372534-54-7
2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidin-4-amine

: 100-46-9
benzylamine

: 1372532-44-9
N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

Guidance literature:: With potassium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-butyl alcohol; at 100 ℃; sealed tube; Inert atmosphere;

Reference yield:

: 956034-07-4
2,4-dichloro-furo[3,2-d]pyrimidine

: 175137-46-9
3-amino-5-cyclopropyl-1H-pyrazole

: 1372532-44-9
N₂-benzyl-N₄-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 18 h / 60 °C

2: potassium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 100 °C / sealed tube; Inert atmosphere

With potassium carbonate; triethylamine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; tert-butyl alcohol;