N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

Base Information

Chemical Name:N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide
CAS No.:1428746-10-4
Molecular Formula:C₂₈H₂₃F₂NO₃
Molecular Weight:459.492
Hs Code.:

Synonyms:N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

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Chemical Property of N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

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Technology Process of N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

There total 3 articles about N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 459-57-4
4-fluorobenzaldehyde

: 195969-43-8
N-(2-acetyl-3-oxo-1-phenyl-butyl)-acetamide

: 1428746-10-4
N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

Guidance literature:: N-(2-acetyl-3-oxo-1-phenyl-butyl)-acetamide; With boron trioxide; In N,N-dimethyl-formamide; at 75 ℃; for 0.5h; Inert atmosphere;

4-fluorobenzaldehyde; With boric acid tributyl ester; In N,N-dimethyl-formamide; for 0.0833333h; Further stages; Inert atmosphere;
DOI:10.1002/ardp.201700005

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1428746-10-4
N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / diethyl ether; acetonitrile / 12 h / 20 °C

2.1: boron trioxide / N,N-dimethyl-formamide / 0.5 h / 75 °C / Inert atmosphere

2.2: 0.08 h / Inert atmosphere

With boron trioxide; chloro-trimethyl-silane; In diethyl ether; N,N-dimethyl-formamide; acetonitrile; 1.1: |Mannich Aminomethylation;
DOI:10.1002/ardp.201700005

Reference yield:

: 100-52-7
benzaldehyde

: 1428746-10-4
N-((E)-5-(4-fluorophenyl)-2-((E)-3-(4-fluorophenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / diethyl ether; acetonitrile / 12 h / 20 °C

2.1: boron trioxide / N,N-dimethyl-formamide / 0.5 h / 75 °C / Inert atmosphere

2.2: 0.08 h / Inert atmosphere

With boron trioxide; chloro-trimethyl-silane; In diethyl ether; N,N-dimethyl-formamide; acetonitrile; 1.1: |Mannich Aminomethylation;
DOI:10.1002/ardp.201700005