Pristiq

Base Information

• Chemical Name: Pristiq
• CAS No.: 386750-22-7
• Molecular Formula: C16H25NO2^.C4H6O4^.H2O
• Molecular Weight: 399.485
• Hs Code.: 2922504500
• European Community (EC) Number: 692-113-2
• UNII: ZB22ENF0XR
• DSSTox Substance ID: DTXSID70959511
• Wikidata: Q27295245
• Mol file: 386750-22-7.mol

Synonyms:2-(1-hydroxycyclohexyl)-2-((4-hydroxyphenyl)ethyl)dimethylammonium 3-carboxypropanoate monohydrate;4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol;45,233, WY;45233, WY;desvenlafaxine;desvenlafaxine succinate;Monohydrate, O-desmethylvenlafaxine Succinate;O desmethylvenlafaxine;O desmethylvenlafaxine Succinate;O desmethylvenlafaxine Succinate Monohydrate;O-desmethylvenlafaxine;O-desmethylvenlafaxine Succinate;O-desmethylvenlafaxine Succinate Monohydrate;Pristiq;Succinate Monohydrate, O-desmethylvenlafaxine;Succinate, Desvenlafaxine;Succinate, O-desmethylvenlafaxine;WY 45,233;WY 45233;WY-45,233;WY-45233;WY45,233;WY45233

Chemical Property of Pristiq

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 3.03E-07mmHg at 25°C
• Boiling Point: 403.8 °C at 760 mmHg
• Flash Point: 193.2 °C
• PSA: 118.30000
• LogP: 2.66840
• Storage Temp.: Store at +4°C
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 399.22570239
• Heavy Atom Count: 28
• Complexity: 359

Purity/Quality:

99.9% ^*data from raw suppliers

Desvenlafaxine(succinatehydrate) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O
• Recent ClinicalTrials: A Study of LY03005 vs Pristiq
• Recent EU Clinical Trials: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Withdrawal, Parallel Group Study to Evaluate the Efficacy and Safety of 50 mg/day of DVS SR in Adult Outpatients With Major Depressive Disorder
• Description: Desvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is also being developed for the treatment of moderate to severe vasomotor symptoms associated with menopause (i.e., hot flashes and night sweats) and is also in phase III clinical trials to study it’s effectiveness in treating fibromyalgia and neuropathic pain.
• Uses: Antianxiety therapeutic

Technology Process of Pristiq

There total 2 articles about Pristiq which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

succinic acid (110-15-6) + O-desmethylvenlafaxine (93413-62-8) → [2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium 3-carboxypropanoate monohydrate (386750-22-7)

Guidance literature:

With water; In isopropyl alcohol; for 1h; Reflux;

Reference yield:

desvenlafaxine succinate (448904-47-0) → [2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium 3-carboxypropanoate monohydrate (386750-22-7)

Guidance literature:

In isopropyl alcohol; at 5 - 20 ℃; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

succinic acid

O-desmethylvenlafaxine

desvenlafaxine succinate

Refernces

• 1、 -. "NOVEL HYDRATE FORM OF O-DESMETHYL VENLAFAXINE SUCCINATE". Page/Page column 10. . Retrieved 2008/06/13.