6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

• Chemical Name: 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
• CAS No.: 1377455-14-5
• Molecular Formula: C₁₅H₁₂F₂N₄OS
• Molecular Weight: 334.349
• Mol file: 1377455-14-5.mol

Synonyms:6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property of 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 1 articles about 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) + methyl 2-(3-amino-2,6-difluorophenyl)acetate (361336-80-3) → 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (1377455-14-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.bmcl.2012.04.015

Reference yield:

6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (1377455-14-5) → C21H21F2N7O3S (1377455-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3: 90 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.04.015

Reference yield:

6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (1377455-14-5) → C18H18F2N4O5S2

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.04.015

upstream raw materials:

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

methyl 2-(3-amino-2,6-difluorophenyl)acetate

Downstream raw materials:

C₁₈H₁₉F₂N₅O₃S

C₂₁H₂₃F₂N₅O₃S

C₁₉H₂₁F₂N₅O₄S

C₂₀H₂₃F₂N₅O₄S