1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

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Chemical Name:1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide
CAS No.:1192313-84-0
Molecular Formula:C₂₆H₃₃F₄N₅O₄
Molecular Weight:555.573
Hs Code.:

1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

Synonyms:1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

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Chemical Property of 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

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Technology Process of 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

There total 7 articles about 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1192313-83-9
lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

: N¹-isopropyl-2-aminoacetamide hydrochloride

: 1192313-84-0
1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

Guidance literature:: lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.75h;

N¹-isopropyl-2-aminoacetamide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: 1192313-84-0
1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 5 °C

2: ethanol / 20 °C

3: PPA / toluene / Inert atmosphere of argon

4: potassium carbonate; potassium iodide / acetone / 65 °C / Inert atmosphere of argon; Reflux

5: lithium hydroxide monohydrate / ethanol; water / 20 °C / Inert atmosphere of argon

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h

With PPA; lithium hydroxide monohydrate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1192313-80-6
1,1-dimethylethyl 2-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}hydrazinecarboxylate

: 1192313-84-0
1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 20 °C

2: PPA / toluene / Inert atmosphere of argon

3: potassium carbonate; potassium iodide / acetone / 65 °C / Inert atmosphere of argon; Reflux

4: lithium hydroxide monohydrate / ethanol; water / 20 °C / Inert atmosphere of argon

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h

With PPA; lithium hydroxide monohydrate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; acetone; toluene;